Reaction Details |
| Report a problem with these data |
Target | Inosine-5'-monophosphate dehydrogenase 2 |
---|
Ligand | BDBM50174782 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_326856 (CHEMBL860455) |
---|
IC50 | 45±n/a nM |
---|
Citation | Birch, HL; Buckley, GM; Davies, N; Dyke, HJ; Frost, EJ; Gilbert, PJ; Hannah, DR; Haughan, AF; Madigan, MJ; Morgan, T; Pitt, WR; Ratcliffe, AJ; Ray, NC; Richard, MD; Sharpe, A; Taylor, AJ; Whitworth, JM; Williams, SC Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors. Bioorg Med Chem Lett15:5335-9 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Inosine-5'-monophosphate dehydrogenase 2 |
---|
Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
|
|
|
BDBM50174782 |
---|
n/a |
---|
Name | BDBM50174782 |
Synonyms: | CHEMBL198729 | N,N-diethyl-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide |
Type | Small organic molecule |
Emp. Form. | C21H27N5O4 |
Mol. Mass. | 413.4702 |
SMILES | CCN(CC)C(=O)N1CCC2(C1)Nc1cc(OC)c(cc1C(=O)N2C)-c1cnco1 |
Structure |
|