| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 2 |
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| Ligand | BDBM50174830 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326855 (CHEMBL860452) |
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| Ki | >3000±n/a nM |
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| Citation |  Palani, A; Shapiro, S; McBriar, MD; Clader, JW; Greenlee, WJ; O'Neill, K; Hawes, B Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett15:5234-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 2 |
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| Name: | Melanin-concentrating hormone receptor 2 |
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| Synonyms: | GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38862.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1 |
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| Residue: | 340 |
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| Sequence: | MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
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| BDBM50174830 |
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| n/a |
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| Name | BDBM50174830 |
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| Synonyms: | CHEMBL198945 | N-[2-(3'-cyano-biphenyl-4-yl)-ethyl]-N-[(3,5-dichloro-phenylcarbamoyl)-methyl]-2-((R)-3-hydroxy-pyrrolidin-1-yl)-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28Cl2N4O3 |
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| Mol. Mass. | 551.464 |
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| SMILES | O[C@@H]1CCN(CC(=O)N(CCc2ccc(cc2)-c2cccc(c2)C#N)CC(=O)Nc2cc(Cl)cc(Cl)c2)C1 |
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| Structure | 
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