Ki Summary

Reaction Details

Report a problem with these data

Target

Melanocortin receptor 4

Ligand

BDBM50174874

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

25±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174874

n/a

Name

BDBM50174874

Synonyms:

Bu-His-DPhe-Arg-2-Nal-Gly-NH2 | CHEMBL369867

Type

Small organic molecule

Emp. Form.

C40H51N11O6

Mol. Mass.

781.903

SMILES

CCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NCC(N)=O |wU:16.16,27.28,6.5,(-6.26,-5.82,;-4.92,-5.06,;-3.6,-5.83,;-2.27,-5.06,;-2.27,-3.52,;-.93,-5.83,;.4,-5.06,;.4,-3.52,;1.74,-2.75,;3.13,-3.37,;4.16,-2.22,;3.39,-.89,;1.89,-1.21,;1.74,-5.83,;1.74,-7.37,;3.07,-5.06,;4.41,-5.83,;4.41,-7.37,;5.73,-8.14,;5.73,-9.68,;7.06,-10.44,;8.39,-9.68,;8.39,-8.13,;7.05,-7.36,;5.73,-5.06,;5.73,-3.52,;7.07,-5.83,;8.4,-5.06,;8.4,-3.52,;9.73,-2.75,;9.73,-1.21,;11.07,-.44,;11.07,1.1,;12.4,1.87,;9.73,1.87,;9.73,-5.83,;9.73,-7.37,;11.07,-5.06,;12.4,-5.83,;12.4,-7.37,;13.74,-8.14,;15.06,-7.37,;16.39,-8.13,;16.4,-9.69,;17.72,-10.46,;17.73,-11.99,;16.38,-12.77,;15.05,-11.99,;15.06,-10.45,;13.72,-9.68,;13.74,-5.06,;13.74,-3.52,;15.07,-5.83,;16.39,-5.06,;17.73,-5.82,;19.05,-5.05,;17.72,-7.35,)|

Structure