Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174883

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

3±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174883

n/a

Name

BDBM50174883

Synonyms:

CHEMBL196773 | X3-Apc-DPhe-Arg-Trp-Z3-NH2

Type

Small organic molecule

Emp. Form.

C50H60N10O6

Mol. Mass.

897.0748

SMILES

C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@]1(CC[C@@H](CC1)c1ccccc1)NC(=O)Cc1ccccc1)C(N)=O |wU:19.28,44.50,30.40,1.0,41.57,wD:41.43,5.17,(22.03,-37.25,;22.04,-38.79,;20.72,-39.56,;19.38,-38.78,;19.38,-37.25,;18.04,-39.56,;18.04,-41.1,;19.38,-41.87,;20.71,-41.09,;21.82,-42.39,;21.05,-43.73,;21.52,-45.19,;20.5,-46.33,;18.98,-46.02,;18.51,-44.55,;19.54,-43.4,;16.7,-38.78,;15.36,-39.56,;15.36,-41.1,;14.02,-38.78,;14.02,-37.25,;15.36,-36.47,;15.36,-34.93,;16.7,-34.16,;16.7,-32.62,;18.04,-31.84,;15.36,-31.84,;12.69,-39.56,;11.35,-38.78,;11.35,-37.25,;10.02,-39.56,;10.02,-41.1,;11.35,-41.87,;11.34,-43.42,;12.68,-44.19,;14.01,-43.42,;14.01,-41.87,;12.67,-41.11,;8.68,-38.78,;7.34,-39.56,;7.34,-41.1,;6.01,-38.79,;7.35,-38.02,;7.35,-36.49,;6.02,-35.72,;4.69,-36.49,;4.68,-38.03,;6.03,-34.19,;7.36,-33.42,;7.37,-31.89,;6.04,-31.12,;4.71,-31.89,;4.71,-33.42,;4.67,-39.56,;3.33,-38.78,;3.33,-37.25,;2,-39.56,;.67,-38.79,;.67,-37.25,;-.65,-36.49,;-1.99,-37.26,;-1.97,-38.8,;-.65,-39.56,;23.37,-39.55,;24.7,-38.78,;23.37,-41.09,)|

Structure