Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174889

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

2±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174889

n/a

Name

BDBM50174889

Synonyms:

CHEMBL434186 | X2-Apc-DPhe-Arg-Trp-Z2-NH2

Type

Small organic molecule

Emp. Form.

C46H61N11O6

Mol. Mass.

864.0466

SMILES

CCCCNC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O |wU:23.24,34.36,11.14,8.7,wD:8.21,45.47,(-9.89,-36.28,;-9.89,-37.81,;-8.57,-38.59,;-7.23,-37.82,;-5.9,-38.6,;-4.57,-37.82,;-4.57,-36.29,;-3.23,-38.6,;-1.88,-37.82,;-.55,-37.06,;-.54,-35.53,;-1.87,-34.75,;-3.2,-35.52,;-3.21,-37.06,;-1.87,-33.22,;-.53,-32.46,;-.52,-30.93,;-1.85,-30.15,;-3.19,-30.92,;-3.19,-32.46,;-.55,-38.6,;-.55,-40.14,;.79,-37.82,;2.13,-38.6,;2.13,-40.14,;3.45,-40.91,;3.45,-42.46,;4.79,-43.22,;6.13,-42.46,;6.12,-40.91,;4.78,-40.14,;3.45,-37.82,;3.45,-36.29,;4.79,-38.6,;6.13,-37.82,;6.13,-36.29,;7.47,-35.51,;7.47,-33.96,;8.81,-33.2,;8.81,-31.65,;10.15,-30.87,;7.47,-30.87,;7.47,-38.6,;7.47,-40.14,;8.81,-37.82,;10.15,-38.6,;10.15,-40.14,;11.49,-40.91,;12.82,-40.13,;13.93,-41.42,;13.16,-42.76,;13.64,-44.23,;12.61,-45.37,;11.1,-45.05,;10.62,-43.58,;11.66,-42.44,;11.49,-37.82,;11.49,-36.29,;12.82,-38.6,;14.16,-37.82,;15.49,-38.58,;16.81,-37.81,;15.49,-40.12,)|

Structure