Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174886

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

11±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174886

n/a

Name

BDBM50174886

Synonyms:

CHEMBL381007 | X3-5-BrAtc-DPhe-Arg-Trp-Z9-NH2

Type

Small organic molecule

Emp. Form.

C52H55BrN10O6

Mol. Mass.

995.96

SMILES

NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(CCc2c(Br)cccc2C1)NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1C(N)=O |wU:11.19,7.7,wD:46.49,(16.07,-25.15,;14.73,-25.92,;13.39,-25.15,;14.73,-27.47,;13.39,-28.24,;13.39,-29.78,;12.05,-30.56,;12.05,-32.1,;10.71,-32.87,;9.37,-32.1,;9.37,-30.56,;8.04,-32.87,;8.04,-34.42,;9.37,-35.19,;9.36,-36.74,;10.7,-37.51,;12.04,-36.74,;12.04,-35.19,;10.7,-34.42,;6.7,-32.1,;5.36,-32.87,;5.36,-34.42,;4.03,-32.1,;5.36,-31.34,;5.37,-29.81,;4.03,-29.03,;4.04,-27.5,;5.37,-26.74,;2.71,-26.73,;1.38,-27.51,;1.38,-29.03,;2.7,-29.8,;2.7,-31.34,;2.68,-32.87,;1.34,-32.1,;1.34,-30.56,;.01,-32.87,;-1.32,-32.11,;-1.31,-30.57,;-2.64,-29.8,;-3.97,-30.57,;-3.97,-32.12,;-2.64,-32.88,;13.39,-32.87,;13.39,-34.42,;14.73,-32.1,;16.07,-32.87,;16.07,-34.42,;17.41,-35.19,;18.75,-34.41,;19.86,-35.71,;19.09,-37.05,;19.56,-38.51,;18.53,-39.66,;17.01,-39.34,;16.54,-37.87,;17.58,-36.72,;17.41,-32.1,;17.41,-30.56,;18.75,-32.87,;20.08,-32.09,;21.1,-33.24,;22.61,-32.91,;23.07,-31.44,;22.03,-30.3,;20.53,-30.64,;19.49,-29.51,;19.95,-28.04,;17.99,-29.84,)|

Structure