| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 4 |
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| Ligand | BDBM50598315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2226719 (CHEMBL5140232) |
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| IC50 | 1447±n/a nM |
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| Citation |  Mahmood, A; Villinger, A; Iqbal, J Therapeutic potentials and structure-activity relationship of 1,3-benzodioxole N-carbamothioyl carboxamide derivatives as selective and potent antagonists of P2X4 and P2X7 receptors. Eur J Med Chem238:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 4 |
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| Name: | P2X purinoceptor 4 |
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| Synonyms: | ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43374.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purinergic, P2X4 0 HUMAN::Q99571 |
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| Residue: | 388 |
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| Sequence: | MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
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| BDBM50598315 |
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| n/a |
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| Name | BDBM50598315 |
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| Synonyms: | CHEMBL5186938 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N2O4S |
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| Mol. Mass. | 316.332 |
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| SMILES | Oc1ccc(NC(=S)NC(=O)c2ccc3OCOc3c2)cc1 |
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| Structure | 
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