| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Ligand | BDBM503741 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2227130 (CHEMBL5140643) |
|---|
| Ki | 0.680000±n/a nM |
|---|
| Citation |  Zhu, Q; Chen, N; Tian, X; Zhou, Y; You, Q; Xu, X Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective. J Med Chem65:8065-8090 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
|---|
| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91316.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586597 |
|---|
| Residue: | 833 |
|---|
| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
|
|
|
|---|
| BDBM503741 |
|---|
| n/a |
|---|
| Name | BDBM503741 |
|---|
| Synonyms: | N-(8-amino-6-(4-methylpyridin-3-yl)-2,7- naphthyridin-3- yl)cyclopropanecarboxamide | US11034692, Compound 24 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H17N5O |
|---|
| Mol. Mass. | 319.3605 |
|---|
| SMILES | Cc1ccncc1-c1cc2cc(NC(=O)C3CC3)ncc2c(N)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
