| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50598960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2228779 (CHEMBL5142292) |
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| IC50 | 19±n/a nM |
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| Citation |  Iijima, D; Sugama, H; Takahashi, Y; Hirai, M; Togashi, Y; Xie, J; Shen, J; Ke, Y; Akatsuka, H; Kawaguchi, T; Takedomi, K; Kashima, A; Nishio, M; Inui, Y; Yoneda, H; Xia, G; Iijima, T Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor. J Med Chem65:10882-10897 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50598960 |
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| n/a |
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| Name | BDBM50598960 |
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| Synonyms: | CHEMBL5176170 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29N5O4 |
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| Mol. Mass. | 415.4861 |
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| SMILES | COC(=O)NCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCCO2)c2cccnc12 |r| |
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| Structure | 
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