| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Ligand | BDBM50599025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2228866 (CHEMBL5142379) |
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| IC50 | 160±n/a nM |
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| Citation |  Huff, S; Kummetha, IR; Zhang, L; Wang, L; Bray, W; Yin, J; Kelley, V; Wang, Y; Rana, TM Rational Design and Optimization of m J Med Chem65:10920-10937 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58263.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515854 |
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| Residue: | 505 |
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| Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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| BDBM50599025 |
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| n/a |
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| Name | BDBM50599025 |
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| Synonyms: | CHEMBL5207866 | US20230322715, Compound TR-FTO-40 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21F3N2OS |
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| Mol. Mass. | 346.411 |
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| SMILES | FC(F)(F)Sc1ccc(CNCC2(COC2)N2CCCC2)cc1 |
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| Structure | 
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