| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
|---|
| Ligand | BDBM50176521 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_327547 (CHEMBL854362) |
|---|
| IC50 | 11600±n/a nM |
|---|
| Citation |  Chambers, RJ; Abrams, K; Garceau, NY; Kamath, AV; Manley, CM; Lilley, SC; Otte, DA; Scott, DO; Sheils, AL; Tess, DA; Vellekoop, AS; Zhang, Y; Lam, KT A new chemical tool for exploring the physiological function of the PDE2 isozyme. Bioorg Med Chem Lett16:307-10 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
|---|
| Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
|---|
| Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 104751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HCR9 |
|---|
| Residue: | 933 |
|---|
| Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
|
|
|
|---|
| BDBM50176521 |
|---|
| n/a |
|---|
| Name | BDBM50176521 |
|---|
| Synonyms: | 5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-carboxylic acid [1,3,4]thiadiazol-2-ylamide | CHEMBL200906 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H10N4O3S |
|---|
| Mol. Mass. | 314.319 |
|---|
| SMILES | CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
