| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase tousled-like 2 |
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| Ligand | BDBM50599378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2230325 (CHEMBL5144097) |
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| IC50 | 19±n/a nM |
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| Citation |  Lee, SB; Chang, TY; Lee, NZ; Yu, ZY; Liu, CY; Lee, HY Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases. Eur J Med Chem227:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase tousled-like 2 |
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| Name: | Serine/threonine-protein kinase tousled-like 2 |
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| Synonyms: | Serine/threonine-protein kinase tousled-like 2 | TLK2 | TLK2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87680.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1510767 |
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| Residue: | 772 |
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| Sequence: | MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ
RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL
PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR
ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT
TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF
DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF
CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN
KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR
CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
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| BDBM50599378 |
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| n/a |
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| Name | BDBM50599378 |
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| Synonyms: | CHEMBL5204542 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N4O2 |
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| Mol. Mass. | 388.4623 |
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| SMILES | CN1CCCC1CCO\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccccc12 |
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| Structure | 
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