| Reaction Details |
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 | Report a problem with these data |
| Target | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Ligand | BDBM50599430 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2230486 (CHEMBL5144258) |
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| IC50 | 98±n/a nM |
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| Citation |  Liu, J; Dai, H; Wang, B; Liu, H; Tian, Z; Zhang, Y Exploring disordered loops in DprE1 provides a functional site to combat drug-resistance in Mycobacterium strains. Eur J Med Chem227:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Name: | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Synonyms: | DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50167.60 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_116793 |
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| Residue: | 461 |
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| Sequence: | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
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| BDBM50599430 |
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| n/a |
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| Name | BDBM50599430 |
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| Synonyms: | CHEMBL5197700 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N3O4S2 |
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| Mol. Mass. | 415.486 |
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| SMILES | O=C(NC(=O)c1ccsc1NC(=O)c1nc2ccccc2s1)OCC1CCC1 |
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| Structure | 
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