| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 3 |
|---|
| Ligand | BDBM12621 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2232495 (CHEMBL5146267) |
|---|
| IC50 | 0.800000±n/a nM |
|---|
| Citation |  Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts. J Med Chem65:6356-6389 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 3 |
|---|
| Name: | Cyclin-dependent kinase 3 |
|---|
| Synonyms: | CDK3 | CDK3/Cyclin E | CDK3_HUMAN | CDKN3 | Cyclin-dependent kinase 3 | Cyclin-dependent kinase 3 (CDK3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35053.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q00526 |
|---|
| Residue: | 305 |
|---|
| Sequence: | MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH
PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS
HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY
TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSF
PKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVL
QRFRH
|
|
|
|---|
| BDBM12621 |
|---|
| n/a |
|---|
| Name | BDBM12621 |
|---|
| Synonyms: | 2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine | R547 | [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21F2N5O4S |
|---|
| Mol. Mass. | 441.452 |
|---|
| SMILES | COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N |
|---|
| Structure | 
|
|---|
Search and Browse
