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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Substance-P receptor | ||
| Ligand | BDBM50178568 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_337893 (CHEMBL868375) | ||
| Ki | 15±n/a nM | ||
| Citation |  Hoffmann, T; Bös, M; Stadler, H; Schnider, P; Hunkeler, W; Godel, T; Galley, G; Ballard, TM; Higgins, GA; Poli, SM; Sleight, AJ Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett16:1362-5 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Substance-P receptor | |||
| Name: | Substance-P receptor | ||
| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 46254.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P25103 | ||
| Residue: | 407 | ||
| Sequence: |
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| BDBM50178568 | |||
| n/a | |||
| Name | BDBM50178568 | ||
| Synonyms: | 1-((3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)methylene)-2-(3,5-dichloropyridin-4-yl)hydrazine | CHEMBL204327 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H10Cl4N4O | ||
| Mol. Mass. | 416.089 | ||
| SMILES | Cc1onc(c1CN=Nc1c(Cl)cncc1Cl)-c1c(Cl)cccc1Cl |w:7.7,(18.91,-20.24,;17.76,-19.21,;16.26,-19.53,;15.5,-18.19,;16.54,-17.05,;17.93,-17.65,;19.26,-16.88,;20.6,-17.64,;21.93,-16.87,;23.26,-17.64,;24.59,-16.86,;24.57,-15.32,;25.92,-17.62,;25.93,-19.17,;24.6,-19.94,;23.26,-19.17,;21.93,-19.94,;16.21,-15.54,;14.75,-15.08,;13.62,-16.12,;14.42,-13.58,;15.57,-12.54,;17.04,-13.01,;17.36,-14.51,;18.82,-14.99,)| | ||
| Structure | 
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