Reaction Details |
| Report a problem with these data |
Target | Prostaglandin G/H synthase 1 |
---|
Ligand | BDBM50179624 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_336082 (CHEMBL865933) |
---|
IC50 | 100±n/a nM |
---|
Citation | Sakya, SM; Cheng, H; Lundy Demello, KM; Shavnya, A; Minich, ML; Rast, B; Dutra, J; Li, C; Rafka, RJ; Koss, DA; Li, J; Jaynes, BH; Ziegler, CB; Mann, DW; Petras, CF; Seibel, SB; Silvia, AM; George, DM; Hickman, A; Haven, ML; Lynch, MP 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers. Bioorg Med Chem Lett16:1202-6 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin G/H synthase 1 |
---|
Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_CANLF | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 |
Type: | PROTEIN |
Mol. Mass.: | 69314.28 |
Organism: | Canis familiaris |
Description: | ChEMBL_327426 |
Residue: | 603 |
Sequence: | MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQC
DCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVL
TARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLL
GRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDN
LDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPG
LMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFL
QLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHY
GIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMS
FQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGN
PICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPS
TEL
|
|
|
BDBM50179624 |
---|
n/a |
---|
Name | BDBM50179624 |
Synonyms: | 5-(2,3-dimethylphenoxy)-1-(5-(methylsulfonyl)pyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile | CHEMBL202856 |
Type | Small organic molecule |
Emp. Form. | C19H15F3N4O3S |
Mol. Mass. | 436.408 |
SMILES | Cc1cccc(Oc2c(C#N)c(nn2-c2ccc(cn2)S(C)(=O)=O)C(F)(F)F)c1C |
Structure |
|