Reaction Details |
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Target | Pteridine reductase, putative |
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Ligand | BDBM50600691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2234681 (CHEMBL5148453) |
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IC50 | 30±n/a nM |
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Citation | Pöhner, I; Quotadamo, A; Panecka-Hofman, J; Luciani, R; Santucci, M; Linciano, P; Landi, G; Di Pisa, F; Dello Iacono, L; Pozzi, C; Mangani, S; Gul, S; Witt, G; Ellinger, B; Kuzikov, M; Santarem, N; Cordeiro-da-Silva, A; Costi, MP; Venturelli, A; Wade, RC Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J Med Chem65:9011-9033 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Pteridine reductase, putative |
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Name: | Pteridine reductase, putative |
Synonyms: | 1.5.1.33 | Tb08.26N11.790 |
Type: | PROTEIN |
Mol. Mass.: | 40300.57 |
Organism: | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) |
Description: | ChEMBL_101127 |
Residue: | 369 |
Sequence: | MYCTEYKFPCFRHTHTIKLVLLHLRECNGVHPPQFYRRMYEWVGSVVIFSPTIIFAPIHD
PYLEGGEKWRINNIVQGASISVAVKKKRKSPTYPLFRVKGVMEAPAAVVTGAAKRIGRAI
AVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINS
CFRAFGRCDVLVNNASAFYPTPLVQGDHEDNSNGKTVETQVAELIGTNAIAPFLLTMSFA
QRQKGTNPNCTSSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRV
NGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKV
DGGLSLVHA
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BDBM50600691 |
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n/a |
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Name | BDBM50600691 |
Synonyms: | CHEMBL5205559 |
Type | Small organic molecule |
Emp. Form. | C24H30N8O3 |
Mol. Mass. | 478.5468 |
SMILES | CCCOC(=O)C1CCN(CC1)C(=O)c1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1 |
Structure |
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