| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 2 |
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| Ligand | BDBM50511993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2235378 (CHEMBL5149150) |
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| EC50 | 1.3±n/a nM |
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| Citation |  Yang, MH; Russell, JL; Mifune, Y; Wang, Y; Shi, H; Moresco, EMY; Siegwart, DJ; Beutler, B; Boger, DL Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. J Med Chem65:9230-9252 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 2 |
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| Name: | Toll-like receptor 2 |
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| Synonyms: | CD_antigen=CD282 | TLR2_MOUSE | Tlr2 | Toll-like receptor 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 89449.81 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117188 |
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| Residue: | 784 |
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| Sequence: | MLRALWLFWILVAITVLFSKRCSAQESLSCDASGVCDGRSRSFTSIPSGLTAAMKSLDLS
FNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWF
GPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNELE
IKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFS
PLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSES
DVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLK
SLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDI
SRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQ
ELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCE
LLSFTMETPALAQILVDWPDSYLCDSPPRLHGHRLQDARPSVLECHQAALVSGVCCALLL
LILLVGALCHHFHGLWYLRMMWAWLQAKRKPKKAPCRDVCYDAFVSYSEQDSHWVENLMV
QQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFS
HFRLFDENNDAAILVLLEPIERKAIPQRFCKLRKIMNTKTYLEWPLDEGQQEVFWVNLRT
AIKS
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| BDBM50511993 |
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| n/a |
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| Name | BDBM50511993 |
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| Synonyms: | CHEMBL4472879 |
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| Type | Small organic molecule |
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| Emp. Form. | C56H56N6O6 |
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| Mol. Mass. | 909.0804 |
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| SMILES | O=C(N[C@H]1C[C@@H]1c1ccccc1)[C@@H]1CN(C[C@H]1C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)c1ccc(cc1)C(=O)N1C[C@H]([C@@H](C1)C(=O)N[C@H]1C[C@@H]1c1ccccc1)C(=O)N[C@H]1C[C@@H]1c1ccccc1 |r| |
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| Structure | 
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