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TargetRenin
LigandBDBM50601200
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2236015 (CHEMBL5149787)
IC50 1.4±n/a nM
Citation Iijima, DSugama, HAwai, NTakahashi, YTogashi, YTakebe, TXie, JShen, JKe, YAkatsuka, HKawaguchi, TTakedomi, KKashima, ANishio, MInui, YYoneda, HXia, GIijima, T Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med Chem Lett13:1351-1357 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50601200
n/a
NameBDBM50601200
Synonyms:CHEMBL5203297
TypeSmall organic molecule
Emp. Form.C22H30N4O4
Mol. Mass.414.498
SMILESCOC(=O)NCCCn1cc(CN(C2CC2)C(=O)C2CNCCO2)c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: