| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50180787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_327311 (CHEMBL858953) |
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| IC50 | 32.6±n/a nM |
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| Citation |  Betz, SF; Reinhart, GJ; Lio, FM; Chen, C; Struthers, RS Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor. J Med Chem49:637-47 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50180787 |
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| n/a |
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| Name | BDBM50180787 |
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| Synonyms: | (S)-N,N-diisobutyl-2-(2-(4-methoxy-3,5-dimethylphenyl)-3-(1-(phenethylamino)propan-2-yl)-1H-indol-5-yl)-2-methylpropanamide | CHEMBL371722 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H55N3O2 |
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| Mol. Mass. | 609.8836 |
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| SMILES | COc1c(C)cc(cc1C)-c1[nH]c2ccc(cc2c1[C@H](C)CNCCc1ccccc1)C(C)(C)C(=O)N(CC(C)C)CC(C)C |
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| Structure | 
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