| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 2 |
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| Ligand | BDBM50374681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2236416 (CHEMBL5150312) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Xie, Z; Yang, X; Duan, Y; Han, J; Liao, C Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases. J Med Chem64:1283-1345 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 2 |
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| Name: | MAP kinase-activated protein kinase 2 |
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| Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45579.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49137 |
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| Residue: | 400 |
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| Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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| BDBM50374681 |
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| n/a |
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| Name | BDBM50374681 |
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| Synonyms: | CHEMBL257834 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36N6O3S |
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| Mol. Mass. | 548.7 |
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| SMILES | CC(C)(C)CN1CCC(CC1)NC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC5(CCC5)n4c3c2)n1 |
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| Structure | 
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