| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 2 |
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| Ligand | BDBM50257350 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2236429 (CHEMBL5150325) |
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| IC50 | 5.4±n/a nM |
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| Citation |  Xie, Z; Yang, X; Duan, Y; Han, J; Liao, C Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases. J Med Chem64:1283-1345 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-adrenergic receptor kinase 2 |
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| Name: | Beta-adrenergic receptor kinase 2 |
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| Synonyms: | ADRBK2 | ARBK2_HUMAN | BARK2 | GRK3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79721.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_615172 |
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| Residue: | 688 |
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| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
APKFLNKPRSGTVELPKPSLCHRNSNGL
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| BDBM50257350 |
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| n/a |
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| Name | BDBM50257350 |
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| Synonyms: | CHEMBL1738877 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21F3N6O |
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| Mol. Mass. | 466.4583 |
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| SMILES | Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1 |
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| Structure | 
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