| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A2 |
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| Ligand | BDBM50055366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2237081 (CHEMBL5150977) |
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| IC50 | 228±n/a nM |
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| Citation |  Robello, M; Barresi, E; Baglini, E; Salerno, S; Taliani, S; Settimo, FD The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities. J Med Chem64:3508-3545 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A2 |
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| Name: | Phospholipase A2 |
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| Synonyms: | Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor |
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| Type: | Protein |
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| Mol. Mass.: | 16364.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04054 |
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| Residue: | 148 |
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| Sequence: | MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV
DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC
DRNAAICFSKAPYNKAHKNLDTKKYCQS
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| BDBM50055366 |
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| n/a |
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| Name | BDBM50055366 |
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| Synonyms: | (3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid | (3-Aminooxalyl-1-benzyl-2-ethyl-2,3-dihydro-1H-indol-4-yloxy)-acetic acid | 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid | CHEMBL148674 | Varespladib sodium |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O5 |
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| Mol. Mass. | 380.3939 |
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| SMILES | CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1 |
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| Structure | 
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