| Reaction Details |
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 | Report a problem with these data |
| Target | NEDD8-activating enzyme E1 catalytic subunit |
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| Ligand | BDBM50601505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2237123 (CHEMBL5151019) |
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| IC50 | 9.8±n/a nM |
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| Citation |  Xiong, C; Zhou, L; Tan, J; Song, S; Bao, X; Zhang, N; Ding, H; Zhao, J; He, JX; Miao, ZH; Zhang, A Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold. J Med Chem64:6161-6178 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NEDD8-activating enzyme E1 catalytic subunit |
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| Name: | NEDD8-activating enzyme E1 catalytic subunit |
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| Synonyms: | 6.2.1.- | NEDD8-activating enzyme E1 catalytic subunit | NEDD8-activating enzyme E1C | UBA3 | UBA3_HUMAN | UBE1C | Ubiquitin-activating enzyme 3 | Ubiquitin-activating enzyme E1C | Ubiquitin-like modifier-activating enzyme 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51843.76 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_116863 |
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| Residue: | 463 |
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| Sequence: | MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST
ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI
GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI
SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA
SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR
LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER
KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS
IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS
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| BDBM50601505 |
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| n/a |
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| Name | BDBM50601505 |
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| Synonyms: | CHEMBL5178136 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H38N8O6S |
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| Mol. Mass. | 614.716 |
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| SMILES | CC(C)(C)OC(=O)N1CCC2(C[C@H](Nc3ncnc4n(nnc34)[C@H]3C[C@H](O)[C@H](COS(N)(=O)=O)C3)c3ccccc23)CC1 |r| |
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| Structure | 
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