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TargetNEDD8-activating enzyme E1 catalytic subunit
LigandBDBM50285607
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2237124 (CHEMBL5151020)
IC50 4.0±n/a nM
Citation Xiong, CZhou, LTan, JSong, SBao, XZhang, NDing, HZhao, JHe, JXMiao, ZHZhang, A Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold. J Med Chem64:6161-6178 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NEDD8-activating enzyme E1 catalytic subunit
Name:NEDD8-activating enzyme E1 catalytic subunit
Synonyms:6.2.1.- | NEDD8-activating enzyme E1 catalytic subunit | NEDD8-activating enzyme E1C | UBA3 | UBA3_HUMAN | UBE1C | Ubiquitin-activating enzyme 3 | Ubiquitin-activating enzyme E1C | Ubiquitin-like modifier-activating enzyme 3
Type:PROTEIN
Mol. Mass.:51843.76
Organism:Homo sapiens
Description:ChEMBL_116863
Residue:463
Sequence:
MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST
ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI
GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI
SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA
SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR
LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER
KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS
IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50285607
n/a
NameBDBM50285607
Synonyms:MLN-4924 | MLN-4924003 | Pevonedistat
TypeSmall organic molecule
Emp. Form.C21H25N5O4S
Mol. Mass.443.519
SMILES[H][C@]1(O)C[C@@]([H])(C[C@@]1([H])COS(N)(=O)=O)n1ccc2c(N[C@@]3([H])CCc4ccccc34)ncnc12 |r|
Structure
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