| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50181938 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_345618 (CHEMBL860683) |
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| IC50 | 270±n/a nM |
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| Citation |  Ishida, T; Suzuki, T; Hirashima, S; Mizutani, K; Yoshida, A; Ando, I; Ikeda, S; Adachi, T; Hashimoto, H Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole. Bioorg Med Chem Lett16:1859-63 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50181938 |
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| n/a |
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| Name | BDBM50181938 |
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| Synonyms: | 1-Cyclohexyl-2-[2-fluoro-4-(phenyl-pyridin-3-yl-methoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid | CHEMBL205716 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H28FN3O3 |
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| Mol. Mass. | 521.5814 |
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| SMILES | OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OC(c2ccccc2)c2cccnc2)cc1F |
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| Structure | 
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