| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin-degrading enzyme |
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| Ligand | BDBM50602621 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2241657 (CHEMBL5155867) |
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| EC50 | 14454±n/a nM |
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| Citation |  Kraupner, N; Dinh, CP; Wen, X; Landry, V; Herledan, A; Leroux, F; Bosc, D; Charton, J; Maillard, C; Warenghem, S; Duplan, I; Piveteau, C; Hennuyer, N; Staels, B; Deprez, B; Deprez-Poulain, R Identification of indole-based activators of insulin degrading enzyme. Eur J Med Chem228:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Insulin-degrading enzyme |
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| Name: | Insulin-degrading enzyme |
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| Synonyms: | Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 117968.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14735 |
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| Residue: | 1019 |
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| Sequence: | MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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| BDBM50602621 |
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| n/a |
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| Name | BDBM50602621 |
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| Synonyms: | CHEMBL5204606 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N5O3S |
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| Mol. Mass. | 451.541 |
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| SMILES | N[C@@H](Cc1cn(c2ccccc12)S(=O)(=O)c1ccccc1)C(=O)NCCCn1ccnc1 |r| |
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| Structure | 
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