| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
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| Ligand | BDBM50183850 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_354921 (CHEMBL853168) |
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| IC50 | >10000±n/a nM |
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| Citation |  Hennequin, LF; Ballard, P; Boyle, FT; Delouvrié, B; Ellston, RP; Halsall, CT; Harris, CS; Hudson, K; Kendrew, J; Pease, JE; Ross, HS; Smith, P; Vincent, JL Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: synthesis and structure-activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett16:2672-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Sgk1 |
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| Name: | Serine/threonine-protein kinase Sgk1 |
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| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 48954.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
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| Residue: | 431 |
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| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
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| BDBM50183850 |
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| n/a |
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| Name | BDBM50183850 |
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| Synonyms: | (R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamide | CHEMBL208292 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClFN5O2 |
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| Mol. Mass. | 429.875 |
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| SMILES | COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@@H]1C(N)=O |
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| Structure | 
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