| Reaction Details |
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 | Report a problem with these data |
| Target | DNA nucleotidylexotransferase |
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| Ligand | BDBM50184757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_356789 (CHEMBL861142) |
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| IC50 | 39700±n/a nM |
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| Citation |  Doncaster, JR; Etchells, LL; Kershaw, NM; Nakamura, R; Ryan, H; Takeuchi, R; Sakaguchi, K; Sardarian, A; Whitehead, RC Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase. Bioorg Med Chem Lett16:2877-81 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA nucleotidylexotransferase |
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| Name: | DNA nucleotidylexotransferase |
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| Synonyms: | DNA nucleotidylexotransferase | DNTT | TDT | TDT_HUMAN | Terminal addition enzyme | Terminal deoxynucleotidyltransferase | Terminal transferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58545.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210231 |
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| Residue: | 509 |
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| Sequence: | MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKG
FRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMT
GKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCE
FRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAV
LNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLV
SCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQL
LQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSS
WQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKT
KRIFLKAESEEEIFAHLGLDYIEPWERNA
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| BDBM50184757 |
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| n/a |
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| Name | BDBM50184757 |
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| Synonyms: | (3aR,4R,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadecyl-1-oxo-3a,4,7,7a-tetrahydro-1H-indene-2,4,7-tricarboxylate | CHEMBL449712 |
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| Type | Small organic molecule |
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| Emp. Form. | C48H82O7 |
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| Mol. Mass. | 771.1605 |
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| SMILES | CCCCCCCCCCCCCCCCC1=C(C(=O)OC)C(=O)[C@H]2[C@@H]1[C@@H](C(=O)OC)C(CCCCCCCCCCCCCCCC)=C[C@@H]2C(=O)OCC |c:16,48| |
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| Structure | 
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