| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50604229 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2247236 (CHEMBL5161446) |
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| Kd | 33±n/a nM |
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| Citation |  Li, L; Liu, J; Yang, Z; Zhao, H; Deng, B; Ren, Y; Mai, R; Huang, J; Chen, J Discovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening. Eur J Med Chem233:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50604229 |
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| n/a |
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| Name | BDBM50604229 |
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| Synonyms: | CHEMBL5205540 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19F3N4OS |
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| Mol. Mass. | 420.451 |
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| SMILES | COc1ccc(cc1-c1cc2c(ncnc2s1)N1CC2CCC(C1)N2)C(F)(F)F |TLB:11:17:24:20.21| |
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| Structure | 
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