| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50186132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_371315 (CHEMBL865536) |
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| Ki | 18.0±n/a nM |
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| Citation |  Briner, K; Collado, I; Fisher, MJ; García-Paredes, C; Husain, S; Kuklish, SL; Mateo, AI; O'Brien, TP; Ornstein, PL; Zgombick, J; de Frutos, O Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives. Bioorg Med Chem Lett16:3449-53 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50186132 |
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| n/a |
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| Name | BDBM50186132 |
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| Synonyms: | CHEMBL378411 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-cyclohexyl-2-(2,5-dioxopyrrolidin-1-yl)ethyl)piperazin-1-yl)-1-oxopropan-2-yl)-2-(indolin-2-yl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C35H44ClN5O4 |
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| Mol. Mass. | 634.208 |
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| SMILES | Clc1ccc(C[C@@H](NC(=O)CC2Cc3ccccc3N2)C(=O)N2CCN(CC2)C(CN2C(=O)CCC2=O)C2CCCCC2)cc1 |
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| Structure | 
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