| Reaction Details |
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 | Report a problem with these data |
| Target | Tripartite terminase subunit 3 |
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| Ligand | BDBM50476539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2249483 (CHEMBL5163693) |
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| IC50 | 1400±n/a nM |
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| Citation |  He, T; Edwards, TC; Xie, J; Aihara, H; Geraghty, RJ; Wang, Z 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. J Med Chem65:5830-5849 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tripartite terminase subunit 3 |
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| Name: | Tripartite terminase subunit 3 |
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| Synonyms: | 3.1.-.- | TRM3 | TRM3_HCMVA | Terminase large subunit | Tripartite terminase subunit 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77099.22 |
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| Organism: | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
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| Description: | ChEMBL_120506 |
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| Residue: | 674 |
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| Sequence: | MLRGDSAAKIQERYAELQKRKSHPTSCISTAFTNVATLCRKRYQMMHPELGLAHSCNEAF
LPLMAFCGRHRDYNSPEESQRELLFHERLKSALDKLTFRPCSEEQRASYQKLDALTELYR
DPQFQQINNFMTDFKKWLDGGFSTAVEGDAKAIRLEPFQKNLLIHVIFFIAVTKIPVLAN
RVLQYLIHAFQIDFLSQTSIDIFKQKATVFLVPRRHGKTWFIIPIISFLLKHMIGISIGY
VAHQKHVSQFVLKEVEFRCRHTFARDYVVENKDNVISIDHRGAKSTALFASCYNTNSIRG
QNFHLLLVDEAHFIKKEAFNTILGFLAQNTTKIIFISSTNTTSDSTCFLTRLNNAPFDML
NVVSYVCEEHLHSFTEKGDATACPCYRLHKPTFISLNSQVRKTANMFMPGAFMDEIIGGT
NKISQNTVLITDQSREEFDILRYSTLNTNAYDYFGKTLYVYLDPAFTTNRKASGTGVAAV
GAYRHQFLIYGLEHFFLRDLSESSEVAIAECAAHMIISVLSLHPYLDELRIAVEGNTNQA
AAVRIACLIRQSVQSSTLIRVLFYHTPDQNHIEQPFYLMGRDKALAVEQFISRFNSGYIK
ASQELVSYTIKLSHDPIEYLLEQIQNLHRVTLAEGTTARYSAKRQNRISDDLIIAVIMAT
YLCDDIHAIRFRVS
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| BDBM50476539 |
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| n/a |
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| Name | BDBM50476539 |
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| Synonyms: | CHEMBL437708 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N3O3S |
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| Mol. Mass. | 327.358 |
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| SMILES | Oc1nc(nc(C(=O)NCc2ccccc2)c1O)-c1cccs1 |
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| Structure | 
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