| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 2 |
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| Ligand | BDBM50186813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_376789 (CHEMBL866614) |
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| Ki | >3000±n/a nM |
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| Citation |  Wu, WL; Burnett, DA; Spring, R; Qiang, L; Sasikumar, TK; Domalski, MS; Greenlee, WJ; O'Neill, K; Hawes, BE Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett16:3668-73 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 2 |
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| Name: | Melanin-concentrating hormone receptor 2 |
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| Synonyms: | GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38862.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1 |
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| Residue: | 340 |
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| Sequence: | MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
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| BDBM50186813 |
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| n/a |
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| Name | BDBM50186813 |
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| Synonyms: | 3-[4-(3'-cyano-biphenyl-4-yl)-1-cyclopropylmethyl-piperidin-4-yl]-N-(3,4-difluoro-phenyl)-propionamide | CHEMBL212265 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H31F2N3O |
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| Mol. Mass. | 499.5941 |
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| SMILES | Fc1ccc(NC(=O)CCC2(CCN(CC3CC3)CC2)c2ccc(cc2)-c2cccc(c2)C#N)cc1F |
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| Structure | 
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