Reaction Details | |||
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Target | Melanin-concentrating hormone receptor 1 | ||
Ligand | BDBM50186846 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_376573 (CHEMBL866622) | ||
Ki | 10±n/a nM | ||
Citation | Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett16:3674-8 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanin-concentrating hormone receptor 1 | |||
Name: | Melanin-concentrating hormone receptor 1 | ||
Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 45976.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. | ||
Residue: | 422 | ||
Sequence: |
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BDBM50186846 | |||
n/a | |||
Name | BDBM50186846 | ||
Synonyms: | 4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-[1-(1-methyl-1H-pyrrole-2-carbonyl)-piperidin-4-ylidene]-methyl}-biphenyl-3-carbonitrile | CHEMBL268938 | ||
Type | Small organic molecule | ||
Emp. Form. | C33H25F4N5O | ||
Mol. Mass. | 583.5781 | ||
SMILES | Cn1cccc1C(=O)N1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N |(-.55,-49.12,;-1.7,-48.09,;-3.2,-48.41,;-3.97,-47.07,;-2.94,-45.93,;-1.54,-46.55,;-.2,-45.79,;1.13,-46.56,;-.2,-44.25,;-1.53,-43.47,;-1.53,-41.94,;-.19,-41.18,;1.14,-41.93,;1.14,-43.48,;-.19,-39.64,;1.14,-38.86,;2.55,-39.49,;3.57,-38.34,;5.1,-38.34,;5.87,-37.02,;5.1,-35.68,;5.86,-34.35,;3.57,-35.69,;2.8,-37.01,;1.3,-37.33,;7.41,-37.02,;8.95,-37.01,;7.41,-38.56,;7.41,-35.48,;-1.53,-38.87,;-2.86,-39.64,;-4.2,-38.87,;-4.19,-37.32,;-2.87,-36.55,;-1.53,-37.32,;-5.53,-36.55,;-6.85,-37.32,;-8.19,-36.56,;-8.19,-35.01,;-6.86,-34.24,;-5.52,-35.01,;-6.86,-32.71,;-6.86,-31.17,)| | ||
Structure |