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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Melanin-concentrating hormone receptor 1 | ||
| Ligand | BDBM50186850 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_376573 (CHEMBL866622) | ||
| Ki | 132±n/a nM | ||
| Citation |  Wu, WL; Burnett, DA; Caplen, MA; Domalski, MS; Bennett, C; Greenlee, WJ; Hawes, BE; O'Neill, K; Weig, B; Weston, D; Spar, B; Kowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett16:3674-8 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Melanin-concentrating hormone receptor 1 | |||
| Name: | Melanin-concentrating hormone receptor 1 | ||
| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 45976.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. | ||
| Residue: | 422 | ||
| Sequence: |
| ||
| BDBM50186850 | |||
| n/a | |||
| Name | BDBM50186850 | ||
| Synonyms: | 2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(3'-methanesulfonyl-biphenyl-4-yl)-methyl]-5-fluoro-6-trifluoromethyl-1H-benzoimidazole | CHEMBL378261 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H29F4N3O2S | ||
| Mol. Mass. | 583.639 | ||
| SMILES | CS(=O)(=O)c1cccc(c1)-c1ccc(cc1)C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)=C1CCN(CC2CC2)CC1 |(14.57,4.59,;14.58,3.04,;16.12,3.05,;13.04,3.06,;14.58,1.5,;13.25,.73,;13.25,-.81,;14.59,-1.58,;15.91,-.81,;15.91,.73,;17.24,-1.58,;17.24,-3.12,;18.57,-3.89,;19.91,-3.12,;19.91,-1.57,;18.57,-.81,;21.25,-3.89,;22.58,-3.12,;23.99,-3.74,;25.01,-2.59,;26.54,-2.6,;27.31,-1.27,;26.53,.06,;27.3,1.4,;25.01,.06,;24.24,-1.26,;22.74,-1.58,;28.85,-1.27,;30.39,-1.26,;28.85,-2.81,;28.85,.27,;21.25,-5.43,;19.91,-6.19,;19.91,-7.72,;21.24,-8.5,;21.24,-10.04,;19.9,-10.81,;18.37,-10.81,;19.13,-12.14,;22.58,-7.73,;22.58,-6.18,)| | ||
| Structure | 
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