| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
|---|
| Ligand | BDBM50162094 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_386030 (CHEMBL870300) |
|---|
| IC50 | 48±n/a nM |
|---|
| Citation |  Ontoria, JM; Martìn Hernando, JI; Malancona, S; Attenni, B; Stansfield, I; Conte, I; Ercolani, C; Habermann, J; Ponzi, S; Di Filippo, M; Koch, U; Rowley, M; Narjes, F Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett16:4026-30 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RNA-directed RNA polymerase |
|---|
| Name: | RNA-directed RNA polymerase |
|---|
| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 25173.95 |
|---|
| Organism: | Hepatitis C virus |
|---|
| Description: | Q8JXU8 |
|---|
| Residue: | 229 |
|---|
| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
|
|
|
|---|
| BDBM50162094 |
|---|
| n/a |
|---|
| Name | BDBM50162094 |
|---|
| Synonyms: | 3-Cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid | CHEMBL368884 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21NO2 |
|---|
| Mol. Mass. | 319.3969 |
|---|
| SMILES | OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2c1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
