| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inositol hexakisphosphate kinase 2 |
|---|
| Ligand | BDBM373532 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2251835 (CHEMBL5166045) |
|---|
| IC50 | 580±n/a nM |
|---|
| Citation |  Zhou, Y; Mukherjee, S; Huang, D; Chakraborty, M; Gu, C; Zong, G; Stashko, MA; Pearce, KH; Shears, SB; Chakraborty, A; Wang, H; Wang, X Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions. J Med Chem65:6869-6887 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inositol hexakisphosphate kinase 2 |
|---|
| Name: | Inositol hexakisphosphate kinase 2 |
|---|
| Synonyms: | 2.7.4.- | IHPK2 | IP6K2 | IP6K2_HUMAN | Inositol hexakisphosphate kinase 2 | InsP6 kinase 2 | InsP6K2 | P(i)-uptake stimulator | PiUS |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49188.38 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_119238 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMR
KFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNSDCEPKSKLLRWTTNKKHH
VLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISSQLKHYNPWS
MKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQ
IRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLR
RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAEDLEDLSEESA
DESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHEGQDAGYIFGLQSLIDIVTEI
SEESGE
|
|
|
|---|
| BDBM373532 |
|---|
| n/a |
|---|
| Name | BDBM373532 |
|---|
| Synonyms: | US9903855, Molecule 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H11NO3 |
|---|
| Mol. Mass. | 265.2634 |
|---|
| SMILES | OC(=O)\C=C\c1ccc2c(onc2c1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
