| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50605747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2252843 (CHEMBL5167053) |
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| IC50 | 0.100000±n/a nM |
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| Citation |  Armani, E; Capaldi, C; Bagnacani, V; Saccani, F; Aquino, G; Puccini, P; Facchinetti, F; Martucci, C; Moretto, N; Villetti, G; Patacchini, R; Civelli, M; Hurley, C; Jennings, A; Alcaraz, L; Bloomfield, D; Briggs, M; Daly, S; Panchal, T; Russell, V; Wicks, S; Finch, H; Fitzgerald, M; Fox, C; Delcanale, M Design, Synthesis, and Biological Characterization of Inhaled p38?/? MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem65:7170-7192 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50605747 |
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| n/a |
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| Name | BDBM50605747 |
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| Synonyms: | CHEMBL5173417 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H39N7O2 |
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| Mol. Mass. | 577.7192 |
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| SMILES | CC(C)c1nnc2ccc(O[C@H]3CC[C@H](NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)cn12 |r| |
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| Structure | 
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