Reaction Details | |||
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Target | Prostaglandin D2 receptor 2 | ||
Ligand | BDBM50188308 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_378634 (CHEMBL868656) | ||
IC50 | 18±n/a nM | ||
Citation | Birkinshaw, TN; Teague, SJ; Beech, C; Bonnert, RV; Hill, S; Patel, A; Reakes, S; Sanganee, H; Dougall, IG; Phillips, TT; Salter, S; Schmidt, J; Arrowsmith, EC; Carrillo, JJ; Bell, FM; Paine, SW; Weaver, R Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett16:4287-90 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Prostaglandin D2 receptor 2 | |||
Name: | Prostaglandin D2 receptor 2 | ||
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 43295.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9Y5Y4 | ||
Residue: | 395 | ||
Sequence: |
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BDBM50188308 | |||
n/a | |||
Name | BDBM50188308 | ||
Synonyms: | 2-(3-(8-cyanoquinolin-4-yl)-2,5-dimethyl-1H-indol-1-yl)acetic acid | CHEMBL213495 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H17N3O2 | ||
Mol. Mass. | 355.3893 | ||
SMILES | Cc1c(-c2ccnc3c(cccc23)C#N)c2cc(C)ccc2n1CC(O)=O |(27.67,-17.48,;26.13,-17.49,;25.23,-18.76,;25.71,-20.22,;27.21,-20.52,;27.7,-21.97,;26.68,-23.13,;25.17,-22.82,;24.15,-23.96,;22.66,-23.66,;22.17,-22.2,;23.19,-21.06,;24.68,-21.37,;24.65,-25.42,;25.14,-26.88,;23.74,-18.28,;22.41,-19.05,;21.07,-18.28,;19.73,-19.05,;21.07,-16.73,;22.4,-15.96,;23.74,-16.73,;25.22,-16.24,;25.69,-14.78,;27.19,-14.45,;28.23,-15.59,;27.67,-12.98,)| | ||
Structure |