Reaction Details | |||
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Target | Prostaglandin D2 receptor 2 | ||
Ligand | BDBM50188299 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_378634 (CHEMBL868656) | ||
IC50 | 11±n/a nM | ||
Citation | Birkinshaw, TN; Teague, SJ; Beech, C; Bonnert, RV; Hill, S; Patel, A; Reakes, S; Sanganee, H; Dougall, IG; Phillips, TT; Salter, S; Schmidt, J; Arrowsmith, EC; Carrillo, JJ; Bell, FM; Paine, SW; Weaver, R Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett16:4287-90 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Prostaglandin D2 receptor 2 | |||
Name: | Prostaglandin D2 receptor 2 | ||
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 43295.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9Y5Y4 | ||
Residue: | 395 | ||
Sequence: |
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BDBM50188299 | |||
n/a | |||
Name | BDBM50188299 | ||
Synonyms: | 2-(3-(8-methoxyquinolin-4-yl)-2,5-dimethyl-1H-indol-1-yl)acetic acid | CHEMBL211631 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H20N2O3 | ||
Mol. Mass. | 360.4058 | ||
SMILES | COc1cccc2c(ccnc12)-c1c(C)n(CC(O)=O)c2ccc(C)cc12 |(-5.5,-28.92,;-4.48,-27.76,;-4.97,-26.3,;-6.47,-26,;-6.96,-24.54,;-5.94,-23.4,;-4.44,-23.71,;-3.42,-22.56,;-1.92,-22.86,;-1.43,-24.32,;-2.45,-25.48,;-3.96,-25.16,;-3.9,-21.1,;-3,-19.84,;-1.46,-19.83,;-3.91,-18.59,;-3.44,-17.12,;-1.93,-16.8,;-.89,-17.93,;-1.46,-15.33,;-5.39,-19.07,;-6.72,-18.31,;-8.05,-19.08,;-8.05,-20.62,;-9.39,-21.39,;-6.72,-21.39,;-5.38,-20.63,)| | ||
Structure |