Reaction Details | |||
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Target | Prostaglandin D2 receptor 2 | ||
Ligand | BDBM50188300 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_378634 (CHEMBL868656) | ||
IC50 | 5.4±n/a nM | ||
Citation | Birkinshaw, TN; Teague, SJ; Beech, C; Bonnert, RV; Hill, S; Patel, A; Reakes, S; Sanganee, H; Dougall, IG; Phillips, TT; Salter, S; Schmidt, J; Arrowsmith, EC; Carrillo, JJ; Bell, FM; Paine, SW; Weaver, R Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett16:4287-90 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Prostaglandin D2 receptor 2 | |||
Name: | Prostaglandin D2 receptor 2 | ||
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 43295.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9Y5Y4 | ||
Residue: | 395 | ||
Sequence: |
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BDBM50188300 | |||
n/a | |||
Name | BDBM50188300 | ||
Synonyms: | 2-(2,5-dimethyl-3-(7-(trifluoromethyl)quinolin-4-yl)-1H-indol-1-yl)acetic acid | CHEMBL214304 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H17F3N2O2 | ||
Mol. Mass. | 398.3778 | ||
SMILES | Cc1c(-c2ccnc3cc(ccc23)C(F)(F)F)c2cc(C)ccc2n1CC(O)=O |(11.76,-35.94,;10.22,-35.95,;9.31,-37.22,;9.8,-38.68,;11.3,-38.98,;11.79,-40.43,;10.76,-41.59,;9.25,-41.28,;8.24,-42.42,;6.75,-42.12,;6.26,-40.66,;7.28,-39.52,;8.77,-39.82,;5.73,-43.27,;4.63,-44.36,;6.85,-44.33,;4.61,-42.21,;7.83,-36.74,;6.49,-37.51,;5.16,-36.74,;3.83,-37.51,;5.16,-35.19,;6.49,-34.42,;7.83,-35.19,;9.3,-34.7,;9.77,-33.24,;11.28,-32.91,;12.32,-34.05,;11.76,-31.44,)| | ||
Structure |