| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 17A |
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| Ligand | BDBM50606011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2253368 (CHEMBL5167578) |
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| IC50 | 15±n/a nM |
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| Citation |  Kurz, CG; Preuss, F; Tjaden, A; Cusack, M; Amrhein, JA; Chatterjee, D; Mathea, S; Berger, LM; Berger, BT; Krämer, A; Weller, M; Weiss, T; Müller, S; Knapp, S; Hanke, T Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- J Med Chem65:7799-7817 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 17A |
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| Name: | Serine/threonine-protein kinase 17A |
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| Synonyms: | DRAK1 | ST17A_HUMAN | STK17A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46544.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_109255245 |
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| Residue: | 414 |
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| Sequence: | MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS
LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW
VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR
DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI
SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT
LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE
TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
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| BDBM50606011 |
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| n/a |
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| Name | BDBM50606011 |
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| Synonyms: | CHEMBL5191892 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24N6O3 |
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| Mol. Mass. | 444.4858 |
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| SMILES | C[C@H](NC(=O)c1ccc-2cc1OCCOCCNc1ccn3ncc-2c3n1)c1ccncc1 |r| |
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| Structure | 
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