| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50188391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_362614 (CHEMBL853223) |
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| IC50 | >50000±n/a nM |
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| Citation |  Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening. J Med Chem49:3454-66 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50188391 |
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| n/a |
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| Name | BDBM50188391 |
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| Synonyms: | 4-(2,4-dichlorophenyl)-2-hydroxy-3-(4-methoxy-3-methylbenzoyl)-5-(2-methoxyethyl)cyclopent-2-enone | CHEMBL206908 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22Cl2O5 |
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| Mol. Mass. | 449.324 |
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| SMILES | COCCC1C(C(C(=O)c2ccc(OC)c(C)c2)C(=O)C1=O)c1ccc(Cl)cc1Cl |
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| Structure | 
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