Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50188609 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_364276 (CHEMBL863214) |
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IC50 | 1.9±n/a nM |
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Citation | Hanson, J; Reynaud, D; Qiao, N; Devel, P; Moray, AL; Renard, JF; Kelley, LP; Winum, JY; Montero, JL; Kinsella, BT; Pirotte, B; Pace-Asciak, CR; Dogné, JM Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. J Med Chem49:3701-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50188609 |
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n/a |
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Name | BDBM50188609 |
Synonyms: | CHEMBL209245 | N-benzyl-N'-[2-(4-methylphenylamino)-5-nitrobenzenesulfonyl]urea |
Type | Small organic molecule |
Emp. Form. | C21H20N4O5S |
Mol. Mass. | 440.472 |
SMILES | Cc1ccc(Nc2ccc(cc2S(=O)(=O)NC(=O)NCc2ccccc2)[N+]([O-])=O)cc1 |
Structure |
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