Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50188616 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_364277 (CHEMBL863215) |
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IC50 | 0.7±n/a nM |
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Citation | Hanson, J; Reynaud, D; Qiao, N; Devel, P; Moray, AL; Renard, JF; Kelley, LP; Winum, JY; Montero, JL; Kinsella, BT; Pirotte, B; Pace-Asciak, CR; Dogné, JM Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. J Med Chem49:3701-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50188616 |
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n/a |
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Name | BDBM50188616 |
Synonyms: | CHEMBL379659 | N-n-pentyl-N'-[2-(3, 5-dimethylphenylamino)-5-nitrobenzenesulfonyl]urea |
Type | Small organic molecule |
Emp. Form. | C20H26N4O5S |
Mol. Mass. | 434.509 |
SMILES | CCCCCNC(=O)NS(=O)(=O)c1cc(ccc1Nc1cc(C)cc(C)c1)[N+]([O-])=O |
Structure |
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