| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50189222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_404878 (CHEMBL869282) |
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| Ki | 300±n/a nM |
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| Citation |  Jiang, W; Tucci, FC; Chen, CW; Arellano, M; Tran, JA; White, NS; Marinkovic, D; Pontillo, J; Fleck, BA; Wen, J; Saunders, J; Madan, A; Foster, AC; Chen, C Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett16:4674-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50189222 |
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| n/a |
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| Name | BDBM50189222 |
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| Synonyms: | 3-amino-N-(1-(2-(4-(3-(2,4-dichlorophenyl)propanoyl)piperazin-1-yl)-5-fluorophenyl)-2-ethoxyethyl)propanamide | CHEMBL214204 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33Cl2FN4O3 |
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| Mol. Mass. | 539.47 |
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| SMILES | CCOCC(NC(=O)CCN)c1cc(F)ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl |
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| Structure | 
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