| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
|---|
| Ligand | BDBM50606685 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2261091 (CHEMBL5216102) |
|---|
| IC50 | 5800±n/a nM |
|---|
| Citation |  Shishodia, S; Demetriades, M; Zhang, D; Tam, NY; Maheswaran, P; Clunie-O'Connor, C; Tumber, A; Leung, IKH; Ng, YM; Leissing, TM; El-Sagheer, AH; Salah, E; Brown, T; Aik, WS; McDonough, MA; Schofield, CJ Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J Med Chem64:16609-16625 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-ketoglutarate-dependent dioxygenase FTO |
|---|
| Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
|---|
| Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58263.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1515854 |
|---|
| Residue: | 505 |
|---|
| Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
|
|
|
|---|
| BDBM50606685 |
|---|
| n/a |
|---|
| Name | BDBM50606685 |
|---|
| Synonyms: | CHEMBL5219099 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15N3O6 |
|---|
| Mol. Mass. | 345.3068 |
|---|
| SMILES | COC(=O)c1ccc(Nc2ccc(O)c(n2)C(=O)NCC(O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
