| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M5 |
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| Ligand | BDBM50606944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2261707 (CHEMBL5216718) |
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| IC50 | 111±n/a nM |
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| Citation |  Capstick, RA; Whomble, D; Orsi, DL; Felts, AS; Rodriguez, AL; Vinson, PN; Chang, S; Blobaum, AL; Niswender, CM; Conn, PJ; Jones, CK; Lindsley, CW; Han, C Discovery of a potent M Bioorg Med Chem Lett76:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M5 |
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| Name: | Muscarinic acetylcholine receptor M5 |
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| Synonyms: | ACM5_HUMAN | CHRM5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60102.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517990 |
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| Residue: | 532 |
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| Sequence: | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
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| BDBM50606944 |
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| n/a |
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| Name | BDBM50606944 |
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| Synonyms: | CHEMBL5219691 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N3O4S2 |
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| Mol. Mass. | 443.539 |
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| SMILES | O=C(Nc1ccc2scnc2c1)C1CCN(CC1)S(=O)(=O)c1ccc2OCCc2c1 |
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| Structure | 
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