| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Low molecular weight phosphotyrosine protein phosphatase |
|---|
| Ligand | BDBM50607112 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2262140 (CHEMBL5217151) |
|---|
| IC50 | 36±n/a nM |
|---|
| Citation |  He, R; Wang, J; Yu, ZH; Moyers, JS; Michael, MD; Durham, TB; Cramer, JW; Qian, Y; Lin, A; Wu, L; Noinaj, N; Barrett, DG; Zhang, ZY Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem65:13892-13909 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Low molecular weight phosphotyrosine protein phosphatase |
|---|
| Name: | Low molecular weight phosphotyrosine protein phosphatase |
|---|
| Synonyms: | Acp1 | LMW-PTP | LMW-PTPase | Low molecular weight cytosolic acid phosphatase | Low molecular weight phosphotyrosine protein phosphatase | PPAC_MOUSE |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 18192.04 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_109834 |
|---|
| Residue: | 158 |
|---|
| Sequence: | MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDSAATSTYEVGNPPDYRG
QNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY
|
|
|
|---|
| BDBM50607112 |
|---|
| n/a |
|---|
| Name | BDBM50607112 |
|---|
| Synonyms: | CHEMBL5220114 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H15BrN2O5S |
|---|
| Mol. Mass. | 379.227 |
|---|
| SMILES | OS(=O)(=O)CC(=O)Nc1ccc(N2CCOCC2)c(Br)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
