| Reaction Details |
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 | Report a problem with these data |
| Target | Amiloride-sensitive sodium channel subunit alpha |
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| Ligand | BDBM50190487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_375179 (CHEMBL868533) |
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| IC50 | 7±n/a nM |
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| Citation |  Hirsh, AJ; Molino, BF; Zhang, J; Astakhova, N; Geiss, WB; Sargent, BJ; Swenson, BD; Usyatinsky, A; Wyle, MJ; Boucher, RC; Smith, RT; Zamurs, A; Johnson, MR Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem49:4098-115 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amiloride-sensitive sodium channel subunit alpha |
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| Name: | Amiloride-sensitive sodium channel subunit alpha |
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| Synonyms: | Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel alpha-subunit | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A | SCNNA_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75711.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_375179 |
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| Residue: | 669 |
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| Sequence: | MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
SSTCPLGGP
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| BDBM50190487 |
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| n/a |
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| Name | BDBM50190487 |
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| Synonyms: | CHEMBL212531 | N-(3,5-diamino-6-chloropyrazine-2-carbony)-N'-{4-[4-(2(S)-2,3-dihydroxypropoxy)-phenyl]butyl}guanidine |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26ClN7O4 |
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| Mol. Mass. | 451.907 |
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| SMILES | NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@@H](O)CO)cc1 |w:14.15| |
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| Structure | 
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